3,7-dimethyloct-6-enyl isobutyrate

Endpoint summary

Description of key information

Short term toxicity to fish:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Long term toxicity to fish:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Short term toxicity to aquatic invertebrate:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

 

Study 1: Aim of this study was to assess the short term toxicity of test chemical to aquatic invertebrate daphnia magna. Study was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system for the total exposure period of 48 hrs. The stock solution 100 mg/l was prepared by dissolving colourless liquid in reconstituted water. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with reconstituted test water..0, 6, 10, 17, 29 and 50 mg/l concentrations were used in the study. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. The median effective concentration (EC50) for the test substance, in Daphnia magna was determined to be 18.7 mg/L on the basis of mobility inhibition effects in a 48 hour study. As the chemical was insoluble in normal water, and in the above study chemical dissolved in the medium so that the solubility increases and the effect were observed. But on the above results chemical does not consider to be classified in the category of toxic chemical.

Long term toxicity to aquatic invertebrates:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Toxicity to aquatic algae and cyanobacteria:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thussubstancecan be considered to be hydrophobic in nature. 

 

 

Objective of this study was to observe the action of test chemical when it exposed with the Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) for 72 hrs. Test conducted in accordance with OECD Guideline 201 (Alga, Growth Inhibition Test). The stock solution 100 mg/l was prepared by dissolving colourless liquid in OECD growth medium. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture. 0, 12, 20, 34, 58 and 100 mg/l concentrations were use in the study. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs. Based on the growth rate inhibition of algae Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) due to the exposure of test chemical for 72 hrs, ErC50 value was determine to be 53.5 mg/l. As the chemical was insoluble in normal water having partion log Pow 5.41, and in the above study chemical dissolved in the growth medium so that the solubility increases and the effect were observed. But on the above results chemical does not consider to be classified in the category of toxic chemical.

Toxicity to microorganisms:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Additional information

Short term toxicity to fish:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Long term toxicity to fish:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Short term toxicity to aquatic invertebrate:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

 

Study 1: Aim of this study was to assess the short term toxicity of test chemical to aquatic invertebrate daphnia magna. Study was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system for the total exposure period of 48 hrs. The stock solution 100 mg/l was prepared by dissolving colourless liquid in reconstituted water. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with reconstituted test water..0, 6, 10, 17, 29 and 50 mg/l concentrations were used in the study. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. The median effective concentration (EC50) for the test substance, in Daphnia magna was determined to be 18.7 mg/L on the basis of mobility inhibition effects in a 48 hour study. As the chemical was insoluble in normal water, and in the above study chemical dissolved in the medium so that the solubility increases and the effect were observed. But on the above results chemical does not consider to be classified in the category of toxic chemical.

Long term toxicity to aquatic invertebrates:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.  

Toxicity to aquatic algae and cyanobacteria:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thussubstancecan be considered to be hydrophobic in nature. 

 

 

Objective of this study was to observe the action of test chemical when it exposed with the Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) for 72 hrs. Test conducted in accordance with OECD Guideline 201 (Alga, Growth Inhibition Test). The stock solution 100 mg/l was prepared by dissolving colourless liquid in OECD growth medium. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture. 0, 12, 20, 34, 58 and 100 mg/l concentrations were use in the study. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs. Based on the growth rate inhibition of algae Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) due to the exposure of test chemical for 72 hrs, ErC50 value was determine to be 53.5 mg/l. As the chemical was insoluble in normal water having partion log Pow 5.41, and in the above study chemical dissolved in the growth medium so that the solubility increases and the effect were observed. But on the above results chemical does not consider to be classified in the category of toxic chemical.

Toxicity to microorganisms:

In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is considered scientifically unjustified since there are mitigating factors indicating that aquatic toxicity is unlikely to occur as the test substance is highly insoluble in water. And also having experimental partition coefficient value i.e. Log Pow is 5.4148 at 25 °C. Thus substance can be considered to be hydrophobic in nature.