2'-hydroxyacetophenone

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1980-07-03 to 1980-07-18

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: orientating information about the inhalation hazard; sufficient for evaluation of vapor exposure

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20°C. 12 young adult laboratory rats were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 h. The exposure was subsequently repeated in the same manner. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study (according to Smyth, H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107, 1962).

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

2'-hydroxyacetophenone

EC Number:

204-288-0

EC Name:

2'-hydroxyacetophenone

Cas Number:

118-93-4

Molecular formula:

C8H8O2

IUPAC Name:

1-(2-hydroxyphenyl)ethan-1-one

Details on test material:

- Name of the test substance (as cited in the report): o-Hydroxyacetophenon
- Substance type: organic
- Physical state: liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males: 212. 5 - 235 g; females: 190.7 - 198 g

Administration / exposure

Route of administration:

other: inhalation of volatile parts of the test substance

Type of inhalation exposure:

whole body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

3.54 mg/L

No. of animals per sex per dose:

3 (a total of 12 animals was used for the test)

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Mortality:

No mortality was observed.

Clinical signs:

other: Animals attempt to escape and showed eyelid closure as well as dyspnea during the treatment.

Gross pathology:

No gross internal lesions were detected.