Registration Dossier
Registration Dossier
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EC number: 249-050-7 | CAS number: 28479-22-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-chloro-p-tolyl isocyanate
- EC Number:
- 249-050-7
- EC Name:
- 3-chloro-p-tolyl isocyanate
- Cas Number:
- 28479-22-3
- Molecular formula:
- C8H6ClNO
- IUPAC Name:
- 2-chloro-4-isocyanato-1-methylbenzene
- Details on test material:
- content: 99.0%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: paraffine oil/xylole 4:1
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0, 18.7, 35.7, 79.3, 98.5, 122.0, 180.8 mg/m³
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 71 mg/m³ air
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 110 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- male rats:
control: 0/0/10; 18.7 [mg/m³]: 0/0/5; 35.7 [mg/m³]: 0/5/5; 79.3 [mg/m³]: 1/5/5; 98.5 [mg/m³]: 0/5/5; 122.0 [mg/m³]: 3/5/5; 180.8[mg/m³]: 5/5/5
female rats:
control: 0/0/10; 18.7 [mg/m³]: 0/0/5; 35.7 [mg/m³]: 1/5/5; 79.3 [mg/m³]: 3/5/5; 98.5 [mg/m³]: 3/5/5; 122.0 [mg/m³]: 5/5/5; 180.8[mg/m³]: 5/5/5 - Clinical signs:
- other: concentration > 35.7 mg/m³: laboured breathing, lethargy, ruffled coat, cachexia, cyanosis, bradypnoe, tachaypnoe, serous discharge (nose)
- Body weight:
- cachexia
- Gross pathology:
- inflated lung, pale liver, spleen and kidneys, reddish intestine mucosa
Any other information on results incl. tables
19 mg/m³ were tolerated in a 1 x 4 h exposition without clinical symptoms. 36 mg/m³ was the starting point of mortality
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
- Executive summary:
method: according OECD TG 403
result: LC50 (male) = 110 mg/m³ air; LC50 (female) = 71 mg/m³ air
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