Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-841-6 | CAS number: 127-41-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on the given test chemical
- Author:
- Lalko et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- secondary source
- Title:
- Toxicity Summaries - Test chemical
- Author:
- US EPA
- Year:
- 2 002
- Bibliographic source:
- US EPA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of the given test chemical in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Ionone, methyl-
- EC Number:
- 215-635-0
- EC Name:
- Ionone, methyl-
- Cas Number:
- 1335-46-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- (1E)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)pent-1-en-3-one
- Details on test material:
- - IUPAC Name: Methylionone
- InChI: 1S/C14H22O/c1-10-7-6-8-14(4,5)13(10)9-11(2)12(3)15/h7,9,13H,6,8H2,1-5H3/b11-9+
- Smiles: C1([C@@H](\C=C(\C(C)=O)C)C(=CCC1)C)(C)C
- Molecular formula :C14H22O
- Molecular weight :206.327 g/mole
- Substance type:Organic
- Physical state:Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The test chemical was applied to abraded rabbit skin - Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 8
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 5000 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal toxicity dose (LD50) value was considered to be >5000 mg/kg bw, when 10 rabbits were treated with the given test chemical by dermal application to abraded rabbit skin.
- Executive summary:
Acute dermal toxicity study was conducted by using test chemical in 10 rabbits at the dose concentration of 5000 mg/kg bw by dermal application to abraded rabbit skin.
Animals were observed for mortality after application of the test chemical. No mortality was observed at 5000 mg/kg bw.
Hence, the LD50 value was considered to be >5000 mg/kg bw, when 10 rabbits were treated with the given test chemical by dermal application to abraded rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
