Registration Dossier
Registration Dossier
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EC number: 241-490-8 | CAS number: 17476-04-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-03-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only basic information given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium lithium tri-tert-butoxide hydride
- EC Number:
- 241-490-8
- EC Name:
- Aluminium lithium tri-tert-butoxide hydride
- Cas Number:
- 17476-04-9
- Molecular formula:
- C12H28AlO3.Li
- IUPAC Name:
- aluminium lithium tri-tert-butoxide hydride
- Details on test material:
- - Name of test material: Lithium tri-tert-butoxyaluminum hydride (TBLAH) in tetrahydrofuran (THF)
- Purity: 26.9 %; Tetrahydrofuran (THF): 13 %
- Lot. No: 180-066
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: Mean Breakthrough time
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not specified
- Remarks on result:
- other: Mean Breakthrough time of 119:68 min wwas observed
Any other information on results incl. tables
One run has been performed with 4 replicates. Each run was longer than > 60 minutes. A mean breakthrough time of the 4 replicates of 119.68 minutes was determined. Based on the results of the Corrositex TM Assay, the test article has not to be classified as corrosive according to the UN Dangerous Goods Transport Regulations.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was tested for corrosive properties in the Corrositex TM Assay. Under the conditions of this test, the test substance was found to be not corrosive.
- Executive summary:
The test substance was tested for corrosive properties in the Corrositex TM Assay in a single trial (four replicates) that examines the mean breakthrough time in order to determine the packing group classification. The substance was considered as categroy 2 substance and therefore tested according to Category 2 test criteria. The mean breakthrough time of the 4 replicates was 119.68 (> 60 minutes), therefore, based on the evaluation of the test results the test substance was not considered to be corrosive.
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