Registration Dossier
Registration Dossier
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EC number: 701-043-4 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to international guideline(s), GLP-compliant, performed in recognized contract research organization, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- <= 8.3 mg/L
- Temp.:
- 20 °C
- pH:
- >= 4.6 - <= 5.1
- Details on results:
- The concentration of the test material increased over time from 2.0 mg/L after 24 hours to 3.2 and 8.3 mg/L after 48 and 72 hours, respectively. Simultaneously, the pH decreased from 4.97 (mean of the five replicates) to 4.69 and 4.62.
Although the results showed a tendency of increasing values, the test was not repeated using longer equilibration times since based on the chemical composition of the UVCB substance it is rather likely that the "anhydride component" contained in test material hydrolyses over time resulting in acidification of the test medium and an increased solubility. Substance specific analysis is not possible due to the UVCB nature of the test material.
The highest measured concentration was reported as water solubility. - Conclusions:
- The test materil is slightly soluble (0.1-100 mg/L) Based on the chemical composition of the UVCB substance it is rather likely that the "anhydride component" contained in test material hydrolyses over time resulting in acidification of the test medium and an increased solubility.
Reference
Description of key information
≤ 8.3 mg/L at 20 °C, pH 4.6-5.0 (dependent on incubation time) (OECD 105 and EU A.6)
Key value for chemical safety assessment
Additional information
Water Solubility ≤ 8.3 mg/L at the temperature of 20°C
The concentration of the test material increased over time. Simultaneously, the pH decreased. Hydrolysis of a component of the UVCB substance is assumed.
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