Registration Dossier
Registration Dossier
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EC number: 277-955-7 | CAS number: 74664-50-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The complete read across justification is detailed in section 13. Source study has reliability 1.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 136 g/L
- Temp.:
- 20 °C
- pH:
- 7 - 7.1
- Remarks on result:
- other: ± 5 g/L
- Conclusions:
- Water solubility of test substance was determined to be 136 g/l at 20 °C at pH 7.
- Executive summary:
Method
Test performed according to OECD guideline 105, using flask method.
Results
Water solubility = 136 g/l at 20 °C and pH 7.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- July 30, 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- Principles of method if other than guideline:
- No available information on the method used.
- Type of method:
- flask method
- Water solubility:
- ca. 49.7 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility = 49.7 g/l.
- Executive summary:
Method
The test has been conducted according to EU method A.6. No other information on method is available. Information from migrated NONS file, as per Article 25(3) request, with permission to refer granted by ECHA.
Results
Water solubility = 49.7 g/l.
Referenceopen allclose all
Description of key information
Very soluble in water.
Key value for chemical safety assessment
Additional information
No data on test substance itself was available. A weight of evidence approach was adopted, using Similar Substance 01 and 02 as read across substances. In particular, Similar Substance 01 is an isomer of test substance, differing only for the position of one functional group on an aromatic ring; Similar Substance 02 has structural similarity with test susbtance. A detailed justification of the read across process is attached in section 13.
Based on migrated information from NONS file, as per Article 25(3) request, Similar Substance 01 has water solubility = 49.7 g/l. Permission to refer is granted by ECHA.
As for Similar Substance 02, water solubility at 20 °C and pH 7 is 136 g/l.
Overall, based on available data, test item is expected to be very soluble, above 10 g/l at 20 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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