Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 288-307-8 | CAS number: 85711-47-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400107, a complex mixture of components. Absorption and systemic availability of WS400107 after topical or oral administration are expected to be limited, because of its low water solubility, high lipohilicity (at acidic pH values) and, to some extent, its molecular weight (ca. 300 – 800). However, some dermal absorption of WS400107 or of a fraction of it has been concluded from the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations. In addition, absorption of at least some WS400107, components and/or metabolites of it after oral ingestion was inferred from changes in a number of blood plasma parameters indicative of altered hepatic function in rats after 5 weeks of treatment by oral gavage. In addition, reduced food intake and body weight gain were observed in males at 400 and 1000 mg/kg/day.
Exposure of humans to WS400107 by the inhalation route is unlikely, because of its very low vapour pressure (4 x 10-3Pa at 25°C), its decomposition at high temperature without boiling (> ca. 155°C) and because it is a highly viscous liquid.
All available study results gave no indication regarding the metabolic pathway, distribution or excretion of WS400107. The bioaccumulation potential cannot be judged based on the available studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
