Reaction mass of 4-methylpentane-2,2-diyl dihydroperoxide, dioxybis-4-methylpentane-2,2-diyl dihydroperoxide and methylisobutylketon

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-11-11 to 2013-11-14

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

252 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

7

Details on results:

The determined final result for water solubility of Methyl isobutyl ketone peroxide was an average result for the time points 24, 48 and 72 hours. The pH value of the samples, taken at the different time points, was measured with pH indicator strips.

Sample name	Time period hrs	Final conc. mg/L	Final conc. mg/L	Avg conc. mg/L	Difference %
Erlenmeyer 1 A	24	236	231	231	-
Erlenmeyer 1 B	24	226
Erlenmeyer 2 A	48	257	258	258	10.4
Erlenmeyer 2 B	48	259
Erlenmeyer 2 A	72	269	266	266	3.1
Erlenmeyer 2 B	72	263

 

 

Conclusions:

The test item is considered to be moderately soluble (100-1000 mg/L). The water solubility of the test item was determined to be 252 mg/L at 20 °C and pH=7.

Executive summary:

A study was conducted according to Regulation (EC) No 440/2008 method A.6, OECD TG 105 to determine the water solubility of the test item using a flask method. The determination of the water solubility was performed at a temperature of 20 ± 0.5°C. The test was carried out in 1 L Erlenmeyer flasks. At the time points 24, 48 and 72 hours after adding the test substance duplicate samples were taken from the flasks and were analysed with HPLC in combination with UV detection. The individual results of the time points did not differ by more than 15%. The water solubility was determined to be 252 mg/L at 20 °C and pH=7. The temperature at which the test was conducted varied from 19.9 – 20.1 °C, this is within the set quality criteria of 20 ± 0.5°C. Thus, no observations were made which cause doubt on the validity of the outcome of the study.

Description of key information

The water solubility of the test item was determined to be 252 mg/L at 20 °C and pH=7.

 

Key value for chemical safety assessment

Water solubility:

252 mg/L

at the temperature of:

20 °C

Additional information

A study was conducted according to Regulation (EC) No 440/2008 method A.6, OECD TG 105 to determine the water solubility of the test item using a flask method. The determination of the water solubility was performed at a temperature of 20 ± 0.5°C. The test was carried out in 1 L Erlenmeyer flasks. At the time points 24, 48 and 72 hours after adding the test substance duplicate samples were taken from the flasks and were analysed with HPLC in combination with UV detection. The individual results of the time points did not differ by more than 15%. The water solubility was determined to be 252 mg/L at 20 °C and ph=7. The temperature at which the test was conducted varied from 19.9 – 20.1 °C, this is within the set quality criteria of 20 ± 0.5°C. Thus, no observations were made which cause doubt on the validity of the outcome of the study.