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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Short-term toxicity of quinidine to fish:

In the ECOTOX Database, the toxicity of quinidine sulphate to Anguilla anguilla is is given. The LC0 (24 h) of quinidine sulphate is 30 mg/L. According to this, the LC0 (24 h) of quinidine is 23.04 mg/L.

Short-term toxicity of quinidine to invertebrates:

In this publication of Calleja, 1994 the EC50 of quinidine sulphate for Daphnia magna as well as LC50 for Brachionus calyciflorus and Streptocephalus proboscideus were determined in fresh water for 24 h according to OECD guideline. The EC50 of quinidine sulphate for Daphnia magna is 33.67 mg/l. According to this, the EC50 of quinidine is 25.85 mg/L. The LC50 of quinidine sulphate for Brachionus calyciflorus is 4.90 mg/l and the LC50 for Streptocephalus proboscideus is 4.64 mg/l. According to this, the LC50 of quinidine for Brachionus calyciflorus is 3.76 mg/L and the LC50 for Streptocephalus proboscideus is 3.56 mg/l. Furthermore, in the publication of Lilius, 1994 the EC50 of the read across substance quinidine sulphate for Daphnia magna (Age < 24 h) was determined according to OECD guideline in freshwater for 24 h. The EC50 for Daphnia magna is 44.81 mg/L (0.06 mM). According to this, the EC50 of quinidine is 34.4 mg/L. The LC50 of the read across substance quinidine sulphate for Artemia salina was determined in saltwater for 24 h. The LC50 of quinidine sulphate for Artemia salina is 154.63 mg/l. According to this, the LC50 of quinidine is 118.73 mg/L. Additionally in an own study, the EC50 of the read-across substance quinidine sulphate was determined for Daphnia magna in fresh water for 48 h. The EC50 of quinidine sulphate is 46.7 mg/L. According to this, the EC50 of quinidine is 40.57 mg/l. 

    
          
    
      Short-term toxicity of quinidine to algae:    
    
      The toxicity to cyanobacterium Arthrospira maxima was determined       with a quantum efficiency test. The IC50 is between 200 µM and 400 µM       quinidine. At a concentration of 400 µM (129.77 mg/L) the maximal effect       was obtained and the quantum efficiency is close to 0. At a       concentration of 200 µM quinidine the quantum use efficiency is reduced       but still above 50% of the control. Thus, the IC50 is > 200 µM (64.88       mg/L). The effect was determined over time. For 200 µM quinidine the       maximal effect was observed after 6 hours exposure.    
    
          
    
      Toxicity of quinidine to aquatic plants:    
    
      In the publication of Wink, 1992 the toxicity of quinidine to Lemna       gibba was determined for 6 days. At a concentration of 0.4%       quinidine lead to bleaching. At a concentration of 0.04 % no effects       were observed.    
    
          
    
      Toxicity of quinidine to microorganisms:    
    
      In the study published by Wink, 1998 the bacterial growth inhibition of Bacillus       subtilis, Escherichia coli and Serratia marcescens was       determined. The IC100 of quinidine of all three Bacteria species       is 3 mM (973.25 mg/L). Quinidine has antibacterial activity.