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Environmental fate & pathways

Hydrolysis

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Administrative data

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
no
Radiolabelling:
no
Analytical monitoring:
yes
Remarks:
HPLC-UV
Details on sampling:
Samples were taken at appropiate intervals
Buffers:
Buffer pH 4 Citric acid/NaOH/NaCl; Fluka, order no.: 33643
Buffer pH 7 KH2PO4/Na2HPO4, Fluka, order no.: 33646
Buffer pH 9 Na2B4O7/HCl, Fluka, order no.: 33648
Duration:
3.6 h
pH:
4
Temp.:
20 °C
Initial conc. measured:
3.569 mg/L
Duration:
23 h
pH:
7
Temp.:
20 °C
Initial conc. measured:
3.64 mg/L
Duration:
5 d
pH:
9
Temp.:
20 °C
Initial conc. measured:
3.647 mg/L
Conclusions:
Carboxy-TH-naphthyridin is shown to be hydrolytically unstable at 20 °C at pH 4 and pH 7. The degradation of the test item can be described by first order kinetics. Half-life times were calculated: 0.9 h at pH 4 and 6.8 h at pH 7.
Carboxy-TH-naphthyridin is shown to be hydrolytically stable at 20°C at a pH value 9.
Executive summary:

The tests were performed based on OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties, OECD TG 111, Council Regulation (EC) No 440/2008, Guideline Part C – Methods for the Determination of Ecotoxicity, C.7. “Abiotic Degradation: Hydrolysis as a Function of pH”.

The hydrolysis behaviour of the test item was investigated at 20 °C at pH 4, pH 7 and pH 9 over a period of up to five days. The stability was monitored by HPLC analysis using UV-detection.

Carboxy-TH-naphthyridin is shown to be hydrolytically unstable at 20 °C at pH 4 (t1/2 = 0.9 h) and pH 7 (t1/2 = 6.8 h). The degradation of the test item can be described by first order kinetics.

Carboxy-TH-naphthyridin is shown to be hydrolytically stable at 20°C at a pH value 9. No half-life times were calculated.

Description of key information

The tests were performed based on OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties, OECD TG 111, Council Regulation (EC) No 440/2008, Guideline Part C – Methods for the Determination of Ecotoxicity, C.7. “Abiotic Degradation: Hydrolysis as a Function of pH”.

Carboxy-TH-naphthyridin is shown to be hydrolytically unstable at 20 °C at pH 4 (t1/2 = 0.9 h) and pH 7 (t1/2 = 6.8 h).

Carboxy-TH-naphthyridin is shown to be hydrolytically stable at 20°C at a pH value 9. No half-life times were calculated.

Key value for chemical safety assessment

Half-life for hydrolysis:
6.8 h
at the temperature of:
20 °C

Additional information