Registration Dossier
Registration Dossier
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EC number: 219-637-2 | CAS number: 2487-90-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Original study was not reviewed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
- Objective of study:
- toxicokinetics
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimethoxysilane
- EC Number:
- 219-637-2
- EC Name:
- Trimethoxysilane
- Cas Number:
- 2487-90-3
- Molecular formula:
- C3H10O3Si
- IUPAC Name:
- Trimethoxysilane
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2450 mg/kg trimethoxysilane or 2000 mg/kg methanol
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 3rd:
Metabolite characterisation studies
- Metabolites identified:
- yes
Any other information on results incl. tables
"In rats treated with the silane, the methanol level was high 1 hour after treatment, indicating rapid absorption. The level was still elevated at 24 hours, indicating sustained release of methanol. Animals treated with methanol exhibited a much lower methanol level at 24 hours, showing that methanol alone is metabolized fairly rapidly. Silicon levels after trimethoxysilane administration were elevated at 1 hour and even higher at 4 hours, indicating continuous release of this element."
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
