Registration Dossier
Registration Dossier
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EC number: 215-687-4 | CAS number: 1344-09-8
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 June - 09 August 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.3020 (Honey Bee Acute Contact Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- no attest of authority; California Agricultural Research Inc., Kerman, CA, USA
- Application method:
- contact
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- - Method of test material application: single topical dose
- Body part: thorax or abdomen
- Volume of test solution applied: 5 µL
- Controls: untreated and with 5 µL sterile water
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): sterile water - Test organisms (species):
- Apis mellifera
- Animal group:
- Hymenoptera (honeybees)
- Details on test organisms:
- TEST ORGANISM
- Common name: honey bee, Italien strain
- Source: California Agricultural Reserach (CAR) Inc. bee yard (hives originally created in 2000 from packaged bees shipped by Bear River Honey Company, Wheatland, CA.)
- Age at test initiation (mean and range, SD): 1 to 5 days
- Cultural background (if honeybees):
- Disease free: yes
- Kept according to standard practices: yes
ACCLIMATION
- Acclimation: CAR bee yard; prior to study start all hives were inventoried for their general health, vigor, and brood conditions
- Health during acclimation (any mortality observed): no - Study type:
- laboratory study
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 4, 6, 24, and 48 h
- Test temperature:
- 26.73° to 35.79°C
- Humidity:
- 31% - 74%
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): cube-shaped, wire mesh cages, appr. 12.7 cm to a side, constructed of 3.2 mesh/cm2 hardware cloth
- Amount of soil or substrate:
- No. of organisms per container (treatment): 40 - 45
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
- No. of replicates per vehicle control: 4
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality
VEHICLE CONTROL PERFORMED: yes - Nominal and measured concentrations:
- 25 µL a.i./bee
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- LD0
- Effect conc.:
- 25 µg per animal
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 25 µg per animal
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: zero
- Morphological abnormalities: none
- Behavioural abnormalities: none - Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to category justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Application method:
- contact
- Duration:
- 48 h
- Dose descriptor:
- LD0
- Effect conc.:
- 25 µg per animal
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Source, key, 1312-76-1, Richards 2006
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 25 µg per animal
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Source, key, 1312-76-1, Richards 2006
Referenceopen allclose all
Under the conditions of this study, there was no evidence of harmful effects or increased mortality caused by acute contact with AgSil ¿ 25.
Description of key information
Key value for chemical safety assessment
Additional information
No test available on sodium silicate. Data considered here is read-across from potassium silicate based on an analogue-approach. In a GLP guideline study with honey bees by Richards (2006), following EPA OPPTS 850.3020 (Honey Bee Acute Contact Toxicity), for a potassium silicate solution (29.1 wt %) the 48 h LD0 and L50 were determined to be 25 ug and > 25 ug active matter per animal, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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