Aluminium oxide

Nanomaterial dustiness

Administrative data

Endpoint:

nanomaterial dustiness

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: DIN 55992-1:2006 ("Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method")

Principles of method if other than guideline:

- Principle of test: modified Heubach procedure
- Short description of test conditions: Heubach dust meter was modified in a way that a seven-stage cascade impactor was inserted instead of a filter.
- Parameters analysed / observed: dustiness, i.e. the proportion of dust arising from solid substances under processing, handling and transportation conditions. Dustiness is considered to reflect the potential of a substance to generate airborne dust after mechanicl stress applied via the dust generation device of the Heubach dust meter (rotating drum).
- Additionaly the dust fractions of the raw material was determined by the cascade impactor.

GLP compliance:

no

Type of method:

rotating cylinder

Test material

Test material information

Constituent 1

Reference substance name:

Aluminium oxide

EC Number:

215-691-6

EC Name:

Aluminium oxide

Cas Number:

1344-28-1

Molecular formula:

Al2O3

IUPAC Name:

oxo[(oxoalumanyl)oxy]alumane

Test material form:

solid: nanoform

Specific details on test material used for the study:

form: High surface area alumina (nanoform)

Results and discussion

Dustiness index

Mean:

607.75 other: mg/g

Remarks on result:

other: total dustiness of the nanoform by modified Heubach procedure

Any other information on results incl. tables

As a conclusion, for the nanoform, the respirable fraction represent 2.13% of the total dustiness generated under the Modified Heubach procedure.

Dustiness in accordance with DIN EN 481:

Total dustiness: 607.75 mg/g

Inhalable fraction: 381.26 mg/g (62.73 %)

Thoraic fraction: 105.65 (17.38 %)

Respirable fraction: 12.94 mg/g (2.13%)

Mass Median Aerodynamic Diameter (MMAD): 24.9 µm

Geometric Standard Deviation (GSD): 2.1 µm

Details on Dustiness:

Table: dust masses and flow values of the impactor stages

Impactor stage	Average aerodyn. diameter [µm]	Calculated physical particles size [µm]	Separated dust mass [mg]	Pass [%]	Residue [%]
A	32.40	16.26	199.93	67.10	32.90
B	15.80	7.93	255.34	25.09	74.91
C	8.13	4.08	114.31	6.28	93.72
D	4.06	2.04	30.72	1.23	98.77
E	2.04	1.02	5.25	0.36	99.64
F	0.99	0.50	1.69	0.08	99.92
G	0.47	0.24	0.39	0.02	99.98
<G	<0.47	<0.24	0.12

Extrapolated total dust quantity: 606.96 mg

Total dust mass, including correction: 607.75 mg

Dust concentration after density correction: 3034.81 mg/m³

 

Table: Characteristics of frequency distribution

Particle size [µm]	Residue [%]	Average particle size d	Slope of cumulated particle size distribution D’
0.24	99.98	0.37	0.25
0.50	99.92	0.76	0.53
1.02	99.64	1.53	0.85
2.04	98.77	3.06	2.47
4.08	93.72	6.01	4.89
7.93	74.91	12.10	5.04
16.26	32.90	37.13	0.52
58.00	11.28	79.0
100.00	0.00

 

Dust masses and values of the sieve and impactor stages for the raw material

 

Sieve stage	Screen size [µm]	Particle size [µm]	Pass [%]	Residue [%]
1	200	200	100	0
2	100	100	96	4
3	63	63	86	14

 

Impactor stage	Average aerodyn. diameter [µm]	Calculated physical particles size [µm]	Separated dust mass [mg]	Pass [%]	Residue [%]
A	32.40	16.26	55.00	31.95	68.05
B	15.80	7.93	15.52	12.74	87.26
C	8.13	4.08	6.63	4.54	95.46
D	4.06	2.04	2.04	2.02	97.98
E	2.04	1.02	0.70	1.14	98.86
F	0.99	0.50	0.54	0.47	99.53
G	0.47	0.24	0.29.	0.11	99.89
<G	<0.47	<0.24	0.09

Extrapolated total dust quantity: 80.81 mg

Total dust mass, including correction: 80.82 mg

Dust concentration after density correction: 404.06 mg/m³