Registration Dossier
Registration Dossier
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EC number: 203-275-7 | CAS number: 105-16-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(diethylamino)ethyl methacrylate
- EC Number:
- 203-275-7
- EC Name:
- 2-(diethylamino)ethyl methacrylate
- Cas Number:
- 105-16-8
- Molecular formula:
- C10H19NO2
- IUPAC Name:
- 2-(diethylamino)ethyl methacrylate
- Reference substance name:
- Diethylaminoethyl Methacrylate
- IUPAC Name:
- Diethylaminoethyl Methacrylate
- Details on test material:
- - Name of test material (as cited in study report): Diethylaminoethyl Methacrylate
- Physical state: liquid, yellowish, clear
- Analytical purity: approx. 99%
- Lot/batch No.: 8800584
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Charle River Wiga GmbH, Germany
- Age at study initiation: about 8-12 weeks
- Weight at study initiation:animals of comparable weigt (160-250 g) (+/-20%)
- Housing: single housing
- Diet (e.g. ad libitum): VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 30 -70
- Photoperiod (hrs dark / hrs light): 12/12 h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- 2000 mg/kg: concentration 40g/100ml (5 ml/kg administration volume) 20% solution in corn oil
- Doses:
- 300, 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mL/kg bw
- Mortality:
- 2000 mg/kg: 3/2
300 mg/kg: 3/0 - Clinical signs:
- other: In one of the two animals which died in the single 2000 mg/kg bw test group impaired general state was noted at hour 0 which increased to poor general state at hour 1, while the other animal showed poor general state from hour 0 until hour 1. Piloerection
- Gross pathology:
- In the two animals that died in the 2000 mg/kg bw test group the following macroscopic pathological findings were observed: swollen small intestine, spotted discolored liver, red discoloration of the glandular stomach, congestion of the kidneys and red discoloration of the whole intestine including the appendix.
There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period (2000 mg/kg bw: 1 female; 300 mg/kg: 6 females)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
