Registration Dossier
Registration Dossier
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EC number: 220-552-8 | CAS number: 2809-21-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a summary report was available for review.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Similar to standard acute toxicity test.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Etidronic acid
- EC Number:
- 220-552-8
- EC Name:
- Etidronic acid
- Cas Number:
- 2809-21-4
- Molecular formula:
- C2H8O7P2
- IUPAC Name:
- (1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
- Details on test material:
- - Name of test material (as cited in study report): HEDP-4-hydrat (described as a solution at pH5, so it is not clear whether the test substance is in fact a sodium salt.
No further details available.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: StammCF w168
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 158, 199, 251, 316 and 398 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 285 mg/kg bw
- 95% CL:
- >= 239 - <= 339
Applicant's summary and conclusion
- Conclusions:
- In an intraperitoneal acute toxicity study (reliability score 4) only available as a summary, the LD50 for HEDP-4-hydrat was 285 mg/kg bw in mice.
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