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REACH

A mixture of RR and RS isomers of: (2-(2-methoxy-1-methyl)ethoxy)-1-methylethyl acetate; (2-(2-methoxy-2-methyl)ethoxy)-1-methylethyl acetate; (2-(2-methoxy-2-methyl)ethoxy)-2-methylethyl acetate; (2-(2-methoxy-1-methyl)ethoxy)-2-methylethyl acetate

EC number: 406-880-6 | CAS number: 88917-22-0 ACETATE DPMA ACROSOLV; ACROSOLV DPMA ACETAT; ACROSOLV DPMA ACETATE; DOWANOL DPMA; DOWANOL DPMA GLYCOL ETHER; DOWANOL DPMA GLYKOL ETHER; ETHER DE GLYCOL DPMA DOWANOL

Life Cycle description
Uses advised against

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

Two inhalation studies in rats and mice are available. Both studies are reliable without restrictions as they were conducted under GLP and according to OECD guideline 453.

Key value for chemical safety assessment

Carcinogenicity: via inhalation route

Endpoint conclusion

Dose descriptor:: NOAEC
: 11 058 mg/m³

Justification for classification or non-classification

No carcinogenic effect as evidenced by any increase in tumor incidence occurred from exposure to PGME at any concentration in either species.

Additional information

Repeated exposure to dipropylene glycol methyl ether acetate resulted in toxicity generally only at high exposure levels and usually consisted of increased organ weights without accompanying histopathology. In vitro genotoxicty studies are negative, indicating that dipropylene glycol methyl ether acetate is not genotoxic. No carcinogenicity studies are available for DPMA.The sole propylene glycol ether that has been subjected to chronic toxicity/carcinogenicity testing is propylene glycol methyl ether (PGME). Thus, the PGME study is used as a surrogate for dipropylene glycol methyl ether acetate. PGME, tested by inhalation in rats at concentrations up to 3,000 ppm, caused very little chronic toxicity and caused no cancer.

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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