Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 231-208-1 | CAS number: 7446-70-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Magnusson, B. and Kligman, A.M.
- Year:
- 1 969
- Bibliographic source:
- J. Invest.Dermatol. 52, 268-276, cited in: Gad, S.C. et al.: Toxicol. Appl.Pharmacol. 84, 93-114 (1986) and Vial, T. and Descotes, J.: Toxicology 93, 63-75 (1995)
Materials and methods
- Principles of method if other than guideline:
- according to Magnusson and Kligman
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- Molecular formula:
- AlCl3
- IUPAC Name:
- trichloroalumane
- Details on test material:
- no data on purity of the compound
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- petrolatum
- Concentration / amount:
- intradermal induction: 2%
topical induction: 25%
challenge: 2%
Challenge
- Concentration / amount:
- intradermal induction: 2%
topical induction: 25%
challenge: 2%
- No. of animals per dose:
- no data
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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