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EC number: 231-826-1 | CAS number: 7757-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The diluted compound was applied in increasing doses at increments of 0.2 fractional log intervals to the closely clipped, intact skin of New Zealand white male and female rabbits. The treated areas were covered with plastic strips and the animals held in wooden stocks for periods up to twenty-four hours, after which time they were assigned to individual cages. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically.
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- calcium hydrogenphosphate dihydrate
- IUPAC Name:
- calcium hydrogenphosphate dihydrate
- Reference substance name:
- Calcium hydrogenorthophosphate
- EC Number:
- 231-826-1
- EC Name:
- Calcium hydrogenorthophosphate
- Cas Number:
- 7757-93-9
- Molecular formula:
- CaHPO4
- IUPAC Name:
- calcium hydrogen phosphate
- Details on test material:
- - Name of test material (as cited in study report): Dicalcium phosphate dihydrate
- Analytical purity: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data pertinent to environmental conditions.
The animals were albinos.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: plastic strips
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 13.026g, 19.056g, 20.644g
- Concentration (if solution): 40.0% suspension
- Constant volume or concentration used: no
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): no data
- Lot/batch no. (if required): no data
- Purity: no data - Duration of exposure:
- 24 h
- Doses:
- 5010 mg/kg bw; 7940 mg/kg bw
- No. of animals per sex per dose:
- 5010 mg/kg bw - 1 female
7940 mg/kg bw - 1 female, 1 male - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: surviving animals were sacrificed 14 days after dosing.
- Frequency of observations and weighing: Bodyweight was recorded 5 days after dosing. There is no other data for observations.
- Necropsy of survivors performed: yes
- Other examinations performed: observations were made for toxic signs and the viscera were examined macroscopically. - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities at the doses tested
- Clinical signs:
- other: Toxic signs included reduced appetite and activity for two to three days.
- Gross pathology:
- The viscera appeared normal by macroscopic examination.
Any other information on results incl. tables
The Acute Skin Absorption Minimal Lethal Dose of dicalcium phosphate dihydrate for rabbits
Sample applied as a 40.0% suspension in corn oil - 24 hour exposure
Animal No. – Sex |
Weight Kg. |
Dose mg/kg |
Weight change 5 days later kg |
Fate |
1 – female |
2.6 |
5010 |
-0.1 |
survived |
2 – male |
2.4 |
7940 |
0.0 |
survived |
3 – female |
2.6 |
7940 |
-0.1 |
survived |
The Acute Skin Absorption Minimal Lethal Dose for male and female rabbits was found to be greater than 7940 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was classified, according to the author, as practically nontoxic to rabbits. The Acute Skin Absorption Minimal Lethal Dose was >7940 mg/kg bw.
This data is considered to meet the regulatory requirements for this endpoint as part of a weight of evidence approach for calcium hydrogenorthophosphate.
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