Registration Dossier
Registration Dossier
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EC number: 232-104-9 | CAS number: 7786-81-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Nickel Sulphate.
- Author:
- Kosova, L.V.
- Year:
- 1 979
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 23:48-49. (H&SE Translation No. 10640).
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Year: 1979 (unclear if "Year of test guideline" or "Year of study completion".)
- GLP compliance:
- not specified
- Test type:
- other: not reported
- Limit test:
- no
Test material
- Reference substance name:
- Nickel sulphate hexahydrate
- IUPAC Name:
- Nickel sulphate hexahydrate
- Reference substance name:
- Nickel sulphate
- EC Number:
- 232-104-9
- EC Name:
- Nickel sulphate
- Cas Number:
- 7786-81-4
- Molecular formula:
- NiSO4
- IUPAC Name:
- nickel(2+) sulfate
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Administration / exposure
- Type of coverage:
- not specified
- Duration of exposure:
- 30 days
- Doses:
- 50% aqueous solution applied daily for 30 days.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 500 other: mg NiSO4.6H2O/kg
- Remarks on result:
- other: as reported in the 2005 Nickel Sulphate Risk Assessment
- Gross pathology:
- No systems pathology found was observed from a 50% aqueous solution applied daily for 30 days.
Applicant's summary and conclusion
- Executive summary:
STUDY RATED BY AN INDEPENDENT REVIEWER.
ROBUST SUMMARY DEVELOPED BY AN INDEPENDENT REVIEWER.
Robust Summary of Kosova 1979:
No systems pathology found was observed from a 50% aqueous solution applied daily for 30 days.
Results from other studies:
A 5% aqueous solution of nickel sulphate proved to be an irritant in some individuals when applied to the back under occlusion (Kalimo, K. andK. Lammintausta. 1984. 24 and 48 hour allergen exposure in patch testing. Contact Dermatit. 10:25-29.).
On the unoccluded human forearm, with the nickel sulphate solution being applied once daily for three days, the threshold concentration ofaqueous nickel sulphate producing irritation was 20% (Frosch, P.J. and A.M. Kligman. 1976. The chamber scarification test for irritancy.
Contact Dermatit. 2:314-324.).
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