Registration Dossier
Registration Dossier
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EC number: 203-917-6 | CAS number: 111-87-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
Key value for chemical safety assessment
Additional information
Experimental data
A comprehensive long-term toxicity study is not available, but a shorter version of an early life stage toxicity test, commonly used as an early screening method, with the test substance is available (see section 6.1.1 Pickering et al. 1996). A 7 day NOEC value equivalent to 1.5 mg/L was determined for the effects of the test substance on survival and growth of the larvae of the freshwater fish Pimephales promelas. The study reflects the only reliable value that is available for this endpoint. However, a longer term toxicity study has been waived.
Testing for long term toxicity to fish is not considered necessary because:
A recent long-term toxicity test has been carried out with decan-1-ol. There was intensive method development to attempt to overcome very significant biodegradation losses of substance in the test system. Whilst testing is not technically impossible, it requires very significant efforts which are disproportionate to the need for data.
The freshwater PNEC has been derived from the data with long-term toxicity to invertebrates (Daphnia). There are three available NOEC values for toxicity to fish across the LCAAs category. These NOEC values indicate that they are in a similar range to the NOEC values that have been determined for long-term toxicity to invertebrates. In addition, the available short-term data set demonstrates that all trophic levels are of similar sensitivity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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