Registration Dossier
Registration Dossier
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EC number: 203-005-8 | CAS number: 102-09-0
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Principles of method if other than guideline:
- Calculated using BCFBAF (v3.01) of EPI Suite (v4.11)
- GLP compliance:
- no
- Type:
- BCF
- Value:
- 64.77 L/kg
- Remarks on result:
- other: Log BCF from regression-based method
- Type:
- BCF
- Value:
- 78.76 dimensionless
- Remarks on result:
- other: Log BCF Arnot-Gobas method
- Conclusions:
- A bioconcentration factor (BCF) of 64.77 L/kg is calculated from the mean octanol-water partition coefficient of 3.25 using the BCFBAF program of EPI-Suite software.
- Executive summary:
A bioconcentration factor (BCF) of 64.77 L/kg is calculated from the mean octanol-water partition coefficient of 3.25 using the BCFBAF program of EPI-Suite software. The estimation methodology is based on the chemical structure of an organic compound and its log octanol-water partition coefficient (Kow).
Reference
The mean logKow of 3.25 is used for calculation.
Description of key information
A bioconcentration factor (BCF) of 64.77 L/kg is calculated from the mean octanol-water partition coefficient of 3.25 using the BCFBAF program of EPI-Suite software.
Key value for chemical safety assessment
- BCF (aquatic species):
- 64.77 L/kg ww
Additional information
A bioconcentration factor (BCF) of 64.77 L/kg is calculated from the mean octanol-water partition coefficient of 3.25 using the BCFBAF program of EPI-Suite software. The estimation methodology is based on the chemical structure of an organic compound and its log octanol-water partition coefficient (Kow).
Bioconcentration of the hydrolysis product phenol was assessed in a European Union Risk Assessment Report (European Chemicals Bureau, 2006). From an experimentally determined bioconcentration factor in fish of 17.5 it can be stated that phenol has only a low bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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