Glyoxylic acid

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Metabolism of labeled 2-arbon Acids in the intact rat.

Author:

Weinhouse S and Friedmann B

Year:

1951

Bibliographic source:

Biological Chemistry 191: 707-717

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

C14 labelled Glyoxylic Acid (0.06 mmol) was administered to rats by i.p. injection together with sodium-benzoate. Doses totaling 1 mmol of sodium-benzoate with the labelled acid as the sodium salt were administered. The rate of oxidation products in urine and the appearance of C-14 activity in exhaled CO2 in urine was studied.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

mixture of glyoxylic acid and sodium benzoate

IUPAC Name:

mixture of glyoxylic acid and sodium benzoate

Radiolabelling:

yes

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

intraperitoneal

Results and discussion

Main ADME results

Type:

excretion

Results:

16 % and 49.1% of applied radioactivity exhaled and excreted in urine, respectively.

Toxicokinetic / pharmacokinetic studies

Details on excretion:

The rate of oxidation as indicated by the appearance of C-14 activity in carbon-dioxide (CO2) was studied at 0.5 hour intervals for 5 hours. Rates of oxalic acid and hippuric acid formation were measured in urine for 24 hours. Glyoxylic Acid was excreted to 16 % in respiratory CO2, 27.1 % as oxalic acid and 22 % as hippuric acid in the urine.

Metabolite characterisation studies

Metabolites identified:

yes

Details on metabolites:

16 % in respiratory CO2, 27.1 % as oxalic acid and 22 % as hippuric acid in the urine.