Registration Dossier
Registration Dossier
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EC number: 211-746-3 | CAS number: 693-23-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Toxicokinetics of dodecandioic acid were investigated in vivo both in experimental rats and in humans following oral or systemic (iv or ip) administration.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Dodecandioic acid was demonstrated in vivo both in rats and human volunteers to be rapidly absorbed fom the gastrointesinal tract. The acid was shown to be introduced into the fatty acid catabolism of the organism and was therefore extensively metabolised. Metabolites are incorporated or metabolised to CO2. Therefore, there is no potential for accumulation.Unchanged or conjugated dodecanedioic acid is not excreted via feces and only to a very low extent via the urine
Discussion on bioaccumulation potential result:
Dodecandioic acid was demonstrated in vivo both in rats and human volunteers to be rapidly absorbed fom the gastrointesinal tract. The acid was shown to be introduced into the fatty acid catabolism of the organism and was therefore extensively metabolised. Metabolites are incorporated or metabolised to CO2. Unchanged or conjugated dodecanedioic acid is not excreted via feces and only to a very low extent via the urine.
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