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Diss Factsheets
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EC number: 918-811-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was given a reliability rating of 1 because it followed a standard test guideline, which describes a procedure to evaluate this endpoint, and the results were reviewed for reliability and assessed as valid. The study was also conducted under GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- However, analysis of the test media was restricted to the media produced at higher loading rates. All media produced at loading rates less 2mg/L
were not analysed because they were below the limit of determination (2.5 mg/L) of the analytical method. - Vehicle:
- no
- Details on test solutions:
- Individual treatment solutions were prepared as Water Accommodated Fractions (WAFs). This included adding test substance to glass vessels,
which contained laboratory dilution water and mixing for approximately 24 hours with a magnetic stirrer to produce a series of geometrically-
spaced loading rates (mg/L). After mixing, the WAFs were allowed to settle for an hour. The aqueous phase was then drawn off and transferred
to 11 litre full-volume, spherical glass vessels which were completely filled. An additional vessel received dechlorinated water only and
served as a control. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- O.mykiss fingerlings were supplied by Exmoor Trout Farm, North Molton, Devon, UK; mean wt. = 0.96 g; mean total length = 4.4 cm.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- Water hardness during the test ranged from 280 - 314 mg/L as CaCO3.
- Test temperature:
- Test temperature was 15 – 16 ºC with a 16 h : 8 h light : dark lighting regime.
- pH:
- The pH ranged from 6.8 to 8.5 during the test.
- Dissolved oxygen:
- Dissolved oxygen = 9.4 to 10.5 mg/L for "new" solutions and 7.5 to 9.3 mg/L for "old" solutions.
- Salinity:
- freshwater
- Nominal and measured concentrations:
- Nominal treatment levels were: control, 0.2, 0.7, 2.0, 5.0, 17 and 50 mg/L. Analysis confirmed concentrations at t=0 of 4.3, 7.5 and 9.5 mg/L for the
nominal loading rates of 5.0, 17 and 50 mg/L, respectively. As there were fish mortalities at these loading rates, no further samples were available
for analysis. All media produced at loading rates less than 2mg/L were not analysed because they were below the limit of determination (2.5 mg/L)
of the analytical method. - Details on test conditions:
- 7 fish were placed in each test vessel, which was then sealed with a glass plate, ensuring that all air was excluded. New WAFs for each treatment
were prepared as described above for each daily renewal. Surviving fish were transferred to the vessel containing freshly prepared WAF. The fish
were not fed during the test.
Test temperature was 15 – 16 ºC with a 16 h : 8 h light : dark lighting regime. Dissolved oxygen = 9.4 to 10.5 mg/L for "new" solution and 7.5 to
9.3 mg/L for "old" solution. The pH ranged from 6.8 to 8.5 during the test. Water hardness during the test ranged from 280 - 314 mg/L as CaCO3.
The water used was harder than the preferred range (10 - 250 mg/L) . However, the hardness measured is normal for this laboratory and does
not affect fish survival. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- >= 2 - <= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- See Table Below
- Reported statistics and error estimates:
- Statistical Method: None required
Loading rates causing a 50% effect were determined by visual inspection of the data. They are expressed as being within a range bounded by
loading rates that were tested. This is considered more appropriate for test materials that are mixtures of substances of different solubilities
than is an interpolative statistical technique - Sublethal observations / clinical signs:
Nominal Loading Measured Fish Total Mortality Conc. (mg/l) Conc. (mg/l) (@ 24, 48, 72, 96 hrs) Control Control 0, 0, 0, 0 0.2 < LoD 0, 0, 0, 0 0.7 < LoD 1, 1, 1, 1 2.0 < LoD 0, 0, 0, 0 5.0 4.3 0, 7, 7, 7 17.0 7.5 7, 7, 7, 7 50.0 9.5 7, 7, 7, 7 - Validity criteria fulfilled:
- yes
- Conclusions:
- Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 96-hour LL50 value between 2 and 5 mg/L with rainbow trout, Oncorhynchus mykiss.
- Executive summary:
Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 96-hour LL50 value between 2 and 5 mg/L with rainbow trout, Oncorhynchus mykiss.
Reference
Description of key information
There is no data available for Hydrocarbons, C10, aromatics, <1% naphthalene. However, data is available for a structural analogue, Hydrocarbons, C10, aromatics, >1% naphthalene and presented in the dossier. This data is read across to based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 96-hour LL50 value between 2 and 5 mg/L with rainbow trout, Oncorhynchus mykiss. In a supporting study, water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 96-hour LL50 value of 14 mg/L with rainbow trout, Oncorhynchus mykiss.
Key value for chemical safety assessment
Additional information
Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 96-hour LL50 value between 2 and 5 mg/L with rainbow trout, Oncorhynchus mykiss.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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