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Diss Factsheets
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EC number: 202-708-7 | CAS number: 98-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Several valid studies dealing with the acute toxicity of acetophenone towards fish are available. In one study the acute toxicity to fish was investigated under flow-through conditions and with analytical monitoring. The study was conducted comparable to OECD guideline 203 'Fish, acute toxicity'. Acetophenone shows a low toxicity towards Pimephales promelas: 96 h LC50 and EC50=162 mg/L measured.
Another study was conducted according to the national standard method US EPA (1975) with analytical monitoring. Based on the results, acetophenone shows a low acute toxicity towards Pimephales promelas (96 h LC50=161 -162 mg/L).
A further study was conducted according to 'Standard practice for conducting acute toxicity tests with fishes, macroinvertebraten, and amphibians (ASTM, 1980) . Test substance concentration were measured daily via GC/FID, GC/ECD and/or HPLC. Based on the results, acetophenone can be regarded as substance with a low acute toxicity towards Pimephales promelas (96 h LC50=236 mg/L). A further study was conducted comparable to US EPA (1975) The concentrations were tested under static conditions and not measured but the test vessels were covered with glass to reduce evaporation. Based on the results, acetophenone shows a low acute toxicity towards Pimephales promelas (96 h LC50=155 mg/L nominal).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 162 mg/L
Additional information
Valid and reliable results from studies conducted comparable to OECD Guideline 203 and according to national standard methods are available. The study of Brooke et al. (1984) was selected as key study due to the test design (flow-through conditions, analytical monitoring of test substance concentration) and the comprehensive documentation although Mattson et al. (1976) found the lowest 96 h LC50 due to the drawbacks of this study (static conditions, no analytical monitoring of test substance concentration, limited documentation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.