Registration Dossier
Registration Dossier
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EC number: 700-455-1 | CAS number: 380843-75-4
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 July 2009-19 August 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- EC Number:
- 700-455-1
- Cas Number:
- 380843-75-4
- Molecular formula:
- C26H29Cl2N5O3
- IUPAC Name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- Details on test material:
- Reference substance
Identification number RS186
Name Sodium acetate
Description White powder (determined at NOTOX)
Molecular formula CH3COONa (taken from label)
Molecular weight 82.03 (taken from label)
Batch number K34333668
Article number 1.06268.0250
Purity ³99.0%
Expiry Date 28 February 2010
Certified Yes
Storage conditions At room temperature in the dark
Supplier Merck, Darmstadt, Germany
Reference substance concentration and preparation of test solutions
A solution of sodium acetate was prepared by dissolving 399.8 mg in Milli-RO water and making this up to a total volume of 100 ml. Volumes of 20 ml from this stock solution were added to 2 litres of the test medium of the positive control bottle and the toxicity control bottle, resulting in a final concentration of 40 mg sodium acetate per litre (12 mg TOC/l).
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Duration of test (contact time):
- ca. 28 d
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 2 - <= 15
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- In conclusion, 3509 is designated as not readily biodegradable.
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