Registration Dossier
Registration Dossier
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EC number: 233-046-7 | CAS number: 10025-87-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Phosphoryl trichloride hydrolyzes in water within seconds, forming phosphoric acid and hydrochloric acid (t1/2 < 10 seconds) (Hansel, 2004). Consequently, microorganisms are exposed to phosphate and chloride ions. Therefore, studies on phosphate and chloride are relevant to analyze the toxicity of phosphoryl trichloride to microorganisms and read across is appropriate.
The effect of chloride ions on activated sludge was investigated. The resulting 3h-EC50 value was calculated to be >1000 mg/L using potassium chloride based on nominal concentration.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
Additional information
Phosphoryl trichloride hydrolyzes in water within seconds, forming phosphoric acid and hydrochloric acid. Consequently, microorganisms are exposed to phosphate and chloride ions. Therefore, studies on phosphate and chloride are relevant to analyze the toxicity of phosphoryl trichloride to microorganisms and read across is appropriate.
A study with chloride ions was reported by Caspers (2010). This study determined effects of potassium chloride on microorganisms and reported 3h-EC50 values of >1000 mg/L.
Studies on phosphate concerning toxicity to microorganisms are not available. But activated sludge, used for microbial toxicity tests, already contains phosphate. Additionally, the synthetic sewage feed used in activated sludge respiration inhibition test (OECD TG 209) exhibits a phosphate concentration of <50 mg/L. Therefore, microbial toxicity is unlikely to occur to phosphate concentrations up to 50 mg/L. Consequently, the study does not need to be conducted using these phosphate concentrations.
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