Registration Dossier
Registration Dossier
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EC number: 201-126-0 | CAS number: 78-59-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- other: Acute Aspiration Toxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,5,5-trimethylcyclohex-2-enone
- EC Number:
- 201-126-0
- EC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Cas Number:
- 78-59-1
- Molecular formula:
- C9H14O
- IUPAC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Details on test material:
- Test substance: other TS: origin: Esso Research and Engineering Company
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Weight at study initiation: 185; 190; 196; 205; 206 g
- Controls: negative: tap water; positive: kerosene
Administration / exposure
- Route of administration:
- other: Aspiration
- Details on exposure:
- ADMINISTRATION: see Method
- Total volume applied: 0.2 ml (undiluted)
- Removal of test substance: no - No. of animals per sex per dose:
- 5
- Details on study design:
- Rats were anesthetized with diethyl ether vapor to the point of apnea and 0.2 ml of the test substance was placed in the mouth of each animal. Animals were held in a vertical position, and nostrils were closed to promote entry of liquid into the trachea. Then animals were returned to their cages for a 24 hour observation period, after which all surviving animals were sacrificed, and lungs were removed from all of the dosed animals.
EXAMINATIONS:
mortality; weight of lung
Results and discussion
- Mortality:
- - Time of death: within minutes after dosing
- Number of deaths at each dose: 3 out of 5 - Gross pathology:
- The weight of the lungs was < 1.5 g for both of the two surviving animals and > 2.5 g for each of the three dead animals.
Applicant's summary and conclusion
- Conclusions:
- Deaths were due to cardiac failure or respiratory arrest or both, rather than pulmonary edema. Isophorone presents potential aspiration hazard.
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