Propyl acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study meets generally accepted scientific principles (restriction: purity unknown)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VII

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 30: 470-476

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1961

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Standardized test protocol using 5 male rats per treatment (dose) with 14 days observation period

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propyl acetate

EC Number:

203-686-1

EC Name:

Propyl acetate

Cas Number:

109-60-4

Molecular formula:

C5H10O2

IUPAC Name:

propyl acetate

Details on test material:

Propyl acetate, purity unknown

Test animals

Species:

rat

Strain:

other: Carworth-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: own breeding
- Age at study initiation: 4-6 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: no
- Diet (e.g. ad libitum): Rockland rat diet


ENVIRONMENTAL CONDITIONS
not reported

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

4.0, 8.0, or 16 mL/kg bw, equivalent to 3.55, 7.10, or 14.21 g/kg bw

No. of animals per sex per dose:

5 males

Control animals:

not specified

Details on study design:

Animals were observed for signs of toxicity after dosing, and throughout the 14-day observation interval. Animals were weighed prior to dosing and at the end of the observation interval. Animals that died on study were subjected to necropsy; surviving animals were sacrificed at the end of the observation interval and necropsied.

Statistics:

Thompson's method of calculating the LD50 was applied to the 14-day mortality data.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 8 700 mg/kg bw

95% CL:

6 600 - 11 450

Remarks on result:

other: corresponding to a LD50 of 9.8 mL (7.5 - 12.9 mL), calculated with a density of 0.888 g/mL as prefered result of the OECD SIDS

Mortality:

Not reported in the publication.

Clinical signs:

other: Not reported in the publication.

Gross pathology:

Not reported in the publication.