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EC number: 425-220-8
CAS number: 5945-33-5
The genotoxicity was investiaged by Durward in 1997 via chromosome
aberration test in CHL cells in vitro and the results indicated that
test material did not have clastogenic effects under the conditions of
Moreover, the laboratory facilities which comply with OECD Principles of
Good Laboratory Practice were utilized in order to ensure the
consistency and reliability for the results.
These two studies were utilized as key studies in substance genetic
toxicity evaluation due to their high adequation, reliablility and
relevance to this element.
Overall, in genotoxicity studies, the test chemical was not mutagenic in
bacteria, nor did it induce an increased incidence of chromosomal
aberrations in Chinese hamster lung cells in vitro. In vivo tests were
According to the existing studies in vitro tests which included
bacterial reverse mutation test and mammalian chromosome aberration test
(Chinese hamster lung cells ) were provided negative results displayed
the BDP was not mutagenic in bacteria, nor did it induce an increased
incidence of chromosomal aberrations. However, in vivo tests were not
provided and further study should be considered.
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