Registration Dossier
Registration Dossier
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EC number: 202-640-8 | CAS number: 98-13-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1951
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not meet current guideline requirements for acute inhalation toxicity. It does however add weight of evidence for trichloro(phenyl)silane toxicity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two methods were employed in determining inhalation toxicity; 1. A 4 hour exposure exposure of 6 rats to 500 and 1000 ppm vapour. 2. Exposure of 6 rats to substantially saturated vapour at room temperature, and the time it took til death.
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Trichloro(phenyl)silane
- EC Number:
- 202-640-8
- EC Name:
- Trichloro(phenyl)silane
- Cas Number:
- 98-13-5
- Molecular formula:
- C6H5Cl3Si
- IUPAC Name:
- trichloro(phenyl)silane
- Details on test material:
- No data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 1.500, 1000 ppm
2. Substantially saturated vapour. - No. of animals per sex per dose:
- 6 animals/dose, sex unspecified
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- discriminating conc.
- Exp. duration:
- 5 min
- Remarks on result:
- other: Time to death for all animals when exposed to substantially saturated vapour
Any other information on results incl. tables
Table 1: Concentrations and mortality per animals treated
Nominal Conc. (ppm) |
Mortality (# dead/total) |
1000 |
3/6
|
500 |
1/6
|
Applicant's summary and conclusion
- Conclusions:
- The mortality data presented here was determined in a study which did not meet current guideline requirements for inhalation toxicity. No LC50 was derived. It does however add to the weight of evidence of trichloro(phenyl)silane toxicity.
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