Registration Dossier
Registration Dossier
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EC number: 201-853-3 | CAS number: 88-72-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions
- Author:
- Vernot EH, MacEwen JD, Haun CC, and Kinkead ER.
- Year:
- 1 977
- Bibliographic source:
- Toxicol Appl Pharmacol 42: 417-442
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report - 2-Nitrotoluene
- Author:
- European Commission - European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- Office for Official Publications of the European Communities
Materials and methods
- Principles of method if other than guideline:
- Single oral dose toxicity was determined by the method of Smyth et al., Am. Ind. Hyg. Ass. J. 30, 470-476 (1962) in which the LD50 and its confidence limits are estimated by the moving average technique (Thompson WR, 1947, Bact Rev 11: 115-145; Weil C.1952, Biometrics 8. 249-263)
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-nitrotoluene
- EC Number:
- 201-853-3
- EC Name:
- 2-nitrotoluene
- Cas Number:
- 88-72-2
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 1-methyl-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): o-nitrotoluene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Weight at study initiation: 200-300g
-Diet: Purina Formulab Chow 5008
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- Not reported
- No. of animals per sex per dose:
- Not reported
- Control animals:
- other: not applicable
- Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 890 mg/kg bw
- 95% CL:
- 500 - 1 580
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Executive summary:
Vernot (1977):
Single oral dose toxicity was determined by the method of Smyth et al., Am. Ind. Hyg. Ass. J. 30, 470-476 (1962) in which the LD50 and its confidence limits are estimated by the moving average technique (Thompson WR, 1947, Bact Rev 11: 115-145; Weil C.1952, Biometrics 8. 249-263)
LD50 was determined to be 890 mg/kg bw (95% CL: 500-1580).
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