Registration Dossier
Registration Dossier
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EC number: 271-091-4 | CAS number: 68515-49-1
Neurotoxicity
Administrative data
Description of key information
A new study by Li et al. found associations between high levels of several low molecular weight phthalates (LMWP) and IQ decreases in 3 year olds.[i] The Li study did not find an association or link between DIDP exposures and IQ changes.
The same pattern was observed in a 2019 systematic review published by Zhang et al. examining the association between prenatal exposure to phthalates, cognition, and neurobehavior.[ii] A systematic review “collect[s] and analyze[s] all evidence that answers a specific question. A thorough search of the literature is performed and a critical analysis of the search results is reported and ultimately provides a current evidence-based answer to the specific question. Zhang’s systematic review identified 26 studies meeting their criteria. Out of these 26 studies, 2 examined DIDP exposures. The results of the Zhang et al. systematic review demonstrates DIDP is not associated with neurobehavioral or cognitive health effect in children.
The existing data support DIDP is not neurotoxic.
[i] Li et al. (2019). Identifying periods of susceptibility to the impact of phthalates on children's cognitive abilities. Environmental Research. 172: 604-614.
[ii] Zhang et al. (2019). The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts. Neurotoxicology. 73:199–212.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
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