3-aminophenol

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June 17 to December 9, 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Principles of method if other than guideline:

The vapour pressure of 3-aminophenol is determined.

GLP compliance:

not specified

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Specific details on test material used for the study:

- Name of test material: 3-aminophenol
- IUPAC name: 1-Hydroxy-3-amino-benzene
- Molecular weight: 109.127 g/mole
- Molecular formula: C6H7NO
- Smiles: c1c(cccc1O)N
- InChI: 1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
- Substance type: Organic
- Physical state: Solid Crystalline (white)

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0.019 Pa

Remarks on result:

other: Extrapoltaed from the regression curve obtained at temperature program 70 °C to 100 °C

Regression curves:

Plot of the log vT of the test item as function of the reciprocal temperatures. The coefficient of correlation (r2) was 0.9378

log vT= -4.1322(1000/T) + 8.4432.

The regression curve for calibration is given by log vT (20°C)=0.8457 log pT (20°C)-4.1989. The coefficient of correlation (r2) was 0.9973

Conclusions:

Vapour pressure of the test item 3-aminophenol is 0.0187 Pa (mean of three determinations) at 20 °C.

Executive summary:

The purpose of the study was to determine the vapour pressure of the test item 3-aminophenol by isothermal thermogravimetry, according to the A4 method and the OECD 104 guideline, and following the GLP. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss. The determination of vapour pressure was done using temperatures below melting range. A value of the vapour pressure of the test item was determined using the data obtained above the 70 °C. The vapour pressure of the test item 3-aminophenol at 20 °C (293K) was calculated to 0.0187 Pa (mean of three determinations).

Description of key information

Vapour pressure of the test item 3-aminophenol is 0.0187 Pa (mean of three determinations) at 20 °C.

Key value for chemical safety assessment

Vapour pressure:

0.019 Pa

at the temperature of:

20 °C

Additional information

The purpose of the study was to determine the vapour pressure of the test item 3-aminophenol by isothermal thermogravimetry, according to the A4 method and the OECD 104 guideline, and following the GLP. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss. The determination of vapour pressure was done using temperatures below melting range. A value of the vapour pressure of the test item was determined using the data obtained above the 70 °C. The vapour pressure of the test item 3-aminophenol at 20 °C (293K) was calculated to 0.0187 Pa (mean of three determinations).

Other supporting data from various authoritative databases, also estimated the vapour pressure of 3-aminophenol as 1.273229 Pa (0.00955 mmHg) at 25°C and 0.24798 Pa (0.00186 mmHg) at 25°C.