Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Endpoint summary
Administrative data
Description of key information
Based on the available information cyclohexylamine has corrosive properties.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Additional information
Skin irritation/corrosion studies indicate that cyclohexylamine has corrosive properties. In one study undiluted test substance was applied to the back of rabbits for 1, 5 min and 20 hours and the animals were observed for up to 8 days after exposure. Necrosis (observed at 24 h and 8 days) was reported after 1 min exposure and marked necrosis after 5 min. After 20 h exposure marked necrosis rounded by significant erythema was observed (BASF 1970). Additional studies mentioned in the IUCLID dossier support that cyclohexylamine has corrosive properties.
Single application of undiluted testsubstance into the conjunctival sac of one rabbits indicated that cyclohexylamine was corrosive to the mucouse membraines, caused hemorrhage and severe not reverible lesions (BASF 1970).
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
According to the EU classification criteria 67/548/EWG Annex 1 the compound is classified with R34. According to EU regulation no. 790/2009 (GHS) the compound is classified Skin Corr 1B.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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