bis(diethylamino)-N,N-diethylmethaniminium chloride

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: expert statement

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Expert statement, based on review of robust and reliable data

Data source

Reference

Reference Type:

other: expert statement

Title:

Unnamed

Report date:

2007

Materials and methods

Principles of method if other than guideline:

Review of relevant studies

Test material

Reference

Name:

Unnamed

Type:

Constituent

Results and discussion

Any other information on results incl. tables

Absorption and metabolism: The high water solubility (>1561 g/l) and the partition coefficient (log Pow -2.9) of the substance indicate that a passive absorption by diffusion through cell membranes including dermal absorption may be limited. According to the results from animal testing, the substance was relatively well absorbed from the gastrointestinal tract and from skin. It can be assumed that the corrosive properties of the substance would have enhanced its uptake. Nevertheless, the bioaccumulation potential is negligible and metabolic degradation such as e.g. enzymatic hydroxylation and transformation of the functional groups is conceivable.

Distribution and excretion: The substance and its metabolites are anticipated to be distributed from the hepatic portal vein into the liver and into the kidneys where the soluble metabolites, including conjugated metabolites, are excreted via urine.

No other indications on the toxicokinetic behaviour of the substance could be derived from the results of the available studies.