Registration Dossier
Registration Dossier
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EC number: 200-831-0 | CAS number: 75-01-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Chloroethylene is a volatile gaseous substance for which inhalation is the most likely route of
exposure. It is extensively studied for its repeated-dose toxicity and the available for this substance experimental data is adequate, relevant and reliable to perform the safety assessment of chloroethylene.
The following toxicity values were observed in studies in rodents:
· The NOEC (inhalation, subchronic, rat)= 130 mg/m3;
· The LOEC (inhalation, subchronic, rat)= 260 mg/m3 (increased relative liver weight);
In conclusion, the currently available repeated-dose toxicity studies ofchloroethylenevia inhalation report carcinogenicity as the most significant toxic effect of long-term exposure tochloroethylene.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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