Registration Dossier
Registration Dossier
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EC number: 939-635-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read across to 2-ethylhexanal, CAS # 123-05-7, EC # 204-596-5:
1) Key study conducted using the OECD Guideline 404 (Acute Dermal Irritation / Corrosion) in 1988 in New Zealand White Rabbit. The potential of 2 -Ethylhexanal to cause acute dermal irritation or corrosion was assessed by a single topical application of 0.5 ml of the test substance to the intact skin of 3 white New Zealand rabbits for 4 hours under semi-occlusive dressing. The average score (24, 48 and 72 hours) for irritation was calculated to be 2.1 for erythema and 0.9 for edema. The irritation findings were reversible in all animals within 14 days. In accordance with the criteria of EU Directive 67/548/EEC, 2-Ethylhexanal is classified as skin irritating (R38).
2) Supporting skin irritation study was conducted in 1978 using an internal standard method (BASF test) using White Vienna Rabbits. Two animals were treated for 4 hours using occlusive conditions. It was concluded that the test substance was irritiating according to the EU criteria used for interpretation of results.
After 4 h of exposure a distinct erythema and edema was observed. The effects were consistent for the next 48 h. Over the course of the next days a distinct improvement of symptoms was observed. At the end of the observation period of 8 days slight erythema with scaling was observed.
3) Supporting skin irritation study was conducted in 1964 using an internal standard method (BASF test) using White Vienna Rabbits. The test substance induced marked Erythema and edema formation even after a 1 min exposure. After 20 h exposure and 8 days observation edemas are questionable while marked scale formation was reported. Scale formation began already after 20 h exposure and 24 h observation. Scale formation is a hint for skin regeneration after skin corrosion. The observed findings are indicating a skin irritating potential of the test substance.
Justification for classification or non-classification
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