Registration Dossier
Registration Dossier
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EC number: 245-528-4 | CAS number: 23255-99-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- June, 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Ames test show prediction values with low reliability index from the software Tox Boxes 2.9.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology. - GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium [[1-(phenylmethyl)-1H-indazol-3-yl]oxy]acetate
- EC Number:
- 245-528-4
- EC Name:
- Sodium [[1-(phenylmethyl)-1H-indazol-3-yl]oxy]acetate
- Cas Number:
- 23255-99-4
- Molecular formula:
- C16H14N2O3.Na
- IUPAC Name:
- sodium [(1-benzyl-1H-indazol-3-yl)oxy]acetate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
other: no alert
No alert came be observed for ames test by Tox Boxes 2.9 (software for the prediction). Ames test show prediction values with low reliability index.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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