Registration Dossier
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EC number: 289-296-2 | CAS number: 87061-04-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72 hour ErC50 = 140 mg/L in Pseudokirchneriella subcapitata
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 140 mg/L
- EC10 or NOEC for freshwater algae:
- 20 mg/L
Additional information
A study was performed to assess the effect of the test material on the growth of the green alga Pseudokirchneriella subcapitata in accordance with the OECD Guidelines for Testing of Chemicals (2006) No 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test" referenced as Method C.3 of Commission Regulation (EC) No 761/2009. The study was conducted under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Following a preliminary range-finding test, Pseudokirchneriella subcapitata was exposed to an aqueous solution of the test material at concentrations of 10, 20, 40, 80 and 160 mg/L (three replicate flasks per concentration) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1°C. Samples of the algal populations were removed daily and cell concentrations determined for each control and treatment group, using a Coulter Multisizer Particle Counter.
Analysis of the test preparations at 0 and 72 hours showed measured test concentrations to range from 94% to 102% of nominal and so the results are based on nominal test concentrations only.
Under the conditions of the study the 72-hour ErC50 was 140 mg/L, the 72-hour NOEC was 20 mg/L.
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