Registration Dossier
Registration Dossier
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EC number: 939-526-9 | CAS number: 90506-73-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 April 2013 to 14 September 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (octadecyloxy)phosphonic acid
- EC Number:
- 939-526-9
- Cas Number:
- 90506-73-3
- Molecular formula:
- C18H39O4P
- IUPAC Name:
- (octadecyloxy)phosphonic acid
- Test material form:
- other: Solid block
- Details on test material:
- Batch number: CEB5-90-3
Storage conditions: roon temperature in the dark
Constituent 1
Test animals / tissue source
- Species:
- cattle
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- Neat
- Duration of post- treatment incubation (in vitro):
- 240 minutes
- Number of animals or in vitro replicates:
- not applicable
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- ca. 22.7
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- A study was performed to assess the ocular irritancy potential of the test materials to the isolated bovine cornea. The test material was considered not to be an ocular corrosive or severe irritant.
- Executive summary:
The test material was considered not to be an ocular corrosive or severe irritant.
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