Registration Dossier
Registration Dossier
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EC number: 939-725-0 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referenced source in an international report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Dimethylformamide, SIDS Initial Assessment Report For SIAM 13
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No further details
- GLP compliance:
- yes
Test material
- Reference substance name:
- N,N-dimethylformamide
- EC Number:
- 200-679-5
- EC Name:
- N,N-dimethylformamide
- Cas Number:
- 68-12-2
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N,N-dimethylformamide
- Details on test material:
- No further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Concentration: undiluted
- Duration of exposure:
- 24 hours
- Doses:
- 3160 mg/kg
- No. of animals per sex per dose:
- 2 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- On days 2, 4, 8, 11 and 15 exposure sites were examined and scored for erythema and edema on a graded scale of 0 to 4. Each animal was observed for mortality and toxic effects 2 and 4 hours post-dosing and daily thereafter.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: Lethal dose
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- not specified
- Mortality:
- In the 14-days post observation period, 1/4 animals died (one male animal) on day 4 of the study.
- Gross pathology:
- Gross necropsy revealed no substance-related effect.
- Other findings:
- Among the remaining animals, no signs of systemic toxicity or percutaneous absorption were observed.
Applicant's summary and conclusion
- Conclusions:
- The lethal dose in an acute dermal toxicity test on rats was found > 3160 mg/kg bw.
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