1,1-dimethylheptanethiol

Specific investigations: other studies

Administrative data

Endpoint:

specific investigations: other studies

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1983-03-31

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was classified as reliable with restrictions because it was an acceptable, well-documented study report which met basic scientific standards.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Principles of method if other than guideline:

No guideline available. Outbred young adult SPF male mice (Charles River Laboratories) were exposed, head only, to the LC50 concentration of Sulfole 90 for one minute, followed by room air for ten minutes, and Sulfole 90 for one minute. The respiratory patterns of the mice were continuously monitored during exposure and for at least five minutes following exposure termination. The basic method was developed by Y. Alarie (Arch. Environ. Health, 13:433-449, 1966).

GLP compliance:

not specified

Type of method:

in vivo

Endpoint addressed:

respiratory irritation

Test material

Test material information

Constituent 1

Reference substance name:

1,1-dimethylheptanethiol (CAS # 25360-10-5)

IUPAC Name:

1,1-dimethylheptanethiol (CAS # 25360-10-5)

Details on test material:

Name of test material (as cited in study report): Sulfole 90

Test animals

Species:

mouse

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

unchanged (no vehicle)

Details on exposure:

- Amount(s) applied (volume or weight with unit): 1067.5 ppm S.D. 3.54 (7.00 mg/L S.D. 0.02)
- Nominal Concentration: 2.54 mg/L

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

Exposure was 1 minute, followed by 10 minutes in room air, followed by another 1 minute exposure.

Post exposure period:

The animals were observed during the exposures and for at least five minutes or until recovery from exposure.

Doses / concentrations

Doses / concentrations 1

Remarks:

Doses / Concentrations:
7.0 mg/L (1067 ppm or 7000 mg/m3)
Basis:
analytical conc.

Doses / concentrations 2

Remarks:

Doses / Concentrations:
2.54 mg/L
Basis:
nominal conc.

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

TEST SITE
- Area of exposure: head only

SCORING SYSTEM: plethysomographic respiratory response

Results and discussion

Details on results:

One mouse experienced a 0-25% decrease in respiratory rate during the first exposure. Two mice experienced the 0-25% decrease in respiratory rate during the second exposure to 7.0 mg/L.

Applicant's summary and conclusion

Conclusions:

In a respiratory irritation tract study, four male outbred SPF mice were exposed via head-only inhalation to 7.00 mg/L (1067.5 ppm) of 1,1-dimethylheptanethiol for two periods of 1 minute exposures separated by a 10 minute exposure to room air. Based on the results the authors concluded that the test material is not an irritant when 7.00 mg/L is inhaled by mice.

Executive summary:

In a respiratory irritation tract study, four male outbred SPF mice were exposed via head-only inhalation to 7.00 mg/L (1067.5 ppm) of 1,1-dimethylheptanethiol for two periods of 1 minute exposures separated by a 10 minute exposure to room air. Animals were then observed for 5 minutes or until the respiratory rate returned to pre-exposure rates.

The test material was applied as a vapour in a head only exposure chamber attached to a plethymograph. One of the four mice demonstrated changes in respiratory rates during the first minute (0 -25% decrease in respiratory rate) and two mice in the second minute (0 -25% decrease in respiratory rate) of exposure to 7.00 mg/L1,1-dimethylheptanethiol. Based on the results the authors concluded that the test material is not an irritant when 7.00 mg/L is inhaled by mice. Compound-induced corrosion was not reported. 

 

This study received a Klimisch score of 2 and was classified as reliable with restrictions because it was an acceptable, well-documented study report which met basic scientific standards.