Registration Dossier
Registration Dossier
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EC number: 610-962-9 | CAS number: 5311-05-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1996
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Reference Type:
- other: Draft Renewal Assessment Report under Regulation (EC) 1107/2009
- Title:
- Draft Renewal Assessment Report under Regulation (EC) 1107/2009 - Tritosulfuron
- Year:
- 2 018
- Bibliographic source:
- Draft Renewal Assessment Report under Regulation (EC) 1107/2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: B.13/B. 14
- Qualifier:
- according to guideline
- Guideline:
- other: EEC 92/69
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 472 (Genetic Toxicology: Escherichia coli, Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine
- EC Number:
- 610-962-9
- Cas Number:
- 5311-05-7
- Molecular formula:
- C5H5F3N4O
- IUPAC Name:
- 4-methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine
Constituent 1
Results and discussion
Any other information on results incl. tables
According to the currently valid OECD TG 471 (1997), approximately half log (i.e. √10 ≈ 3.2) intervals should be used for the dose level selection.
However, since the adequate spacing was not specified by the previous version of OECD TG 471 (1983), some dose groups are spaced by the factor of 5.
Nevertheless, since the mutant frequencies were not increased in any dose group up to the limit dose of 5000 μg/plate, this deviation is considered to be of minor importance and did not compromise the outcome of this study.
Therefore, this study is considered to have a deviation, but be acceptable.proximately half log (i.e. √10 ≈ 3.2) intervals should be used for the dose level selection.
Applicant's summary and conclusion
- Executive summary:
According to the currently valid OECD TG 471 (1997), approximately half log (i.e. √10 ≈ 3.2) intervals should be used for the dose level selection.
However, since the adequate spacing was not specified by the previous version of OECD TG 471 (1983), some dose groups are spaced by the factor of 5.
Nevertheless, since the mutant frequencies were not increased in any dose group up to the limit dose of 5000 μg/plate, this deviation is considered to be of minor importance and did not compromise the outcome of this study.
Therefore, this study is considered to have a deviation, but be acceptable.proximately half log (i.e. √10 ≈ 3.2) intervals should be used for the dose level selection.
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