Registration Dossier
Registration Dossier
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EC number: 700-483-4 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
- EC50 (3h) = 130 mg/L
- NOEC (3h) = 47 mg/L
Key value for chemical safety assessment
- EC50 for microorganisms:
- 130 mg/L
- EC10 or NOEC for microorganisms:
- 47 mg/L
Additional information
The toxicity of 'diallyl 2,2'-oxydiethyl dicarbonate' to microorganisms has been tested under GLP conditions according to OECD 209 activated sludge respiration inhibition test (Youngs, 2010). The effect of the test item on the respiration of activated sewage sludge gave a 3 hour EC50 of 130 mg/L, 95% confidence limits 100 - 160 mg/l. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 47 mg/L.
Since RAV 7NG contains as main ingredient 'diallyl 2,2'oxydiethyl dicarbonate', the experimental data from this substance were used in a read-across approach.
Justification for read-across from supporting substance RAV 7AT (diallyl 2,2'-oxydiethyl dicarbonate; CAS 142-22-3; EC 205-528-7): about 70 % of RAV 7NG (EC 700-483-4) consists of components that can be found in the commercial ADC grades known as RAV 7AT, Nouryset 200 and CR39. Merely from comparing the similar production processes of these two substances it is apparent that RAV 7AT and RAV 7NG are closely related to each other. Finally, the physical-chemical, toxicological and ecotoxicological properties of RAV 7NG and RAV 7AT are almost equal and as a result, read across is justified.
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