Zinc bis(diethyldithiocarbamate)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Comparable to guideline study, perdates GLP, minor restrictions in reporting, but otherwise adequate for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Principles of method if other than guideline:

The test material was suspended in corn oil and orally administered to a group of 10 males and 10 females in one single dose of 5 to 20 ml per kg body weight. After treatment the animals were observed for signs of intoxication during a 14-day period, after which autopsies were carried out on the survivors.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Zinc bis(diethyldithiocarbamate)

EC Number:

238-270-9

EC Name:

Zinc bis(diethyldithiocarbamate)

Cas Number:

14324-55-1

Molecular formula:

C10H20N2S4Zn

IUPAC Name:

zinc bis(diethyldithiocarbamate)

Details on test material:

- Name of test material (as cited in study report): Soxinol EZ (WTR-No. 38 )
- Physical state: White-coloured powder

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Shizuoka Agricultural Cooperative Association for Experimental Animals, Shizuoka
- Age at study initiation: 7-week old
- Weight at study initiation: Male 230-260 g, Female 180-210 g
- Housing: 10 animals/ cage
- Diet: ad libitum
- Water: ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature: 24 ± 1°C
- Humidity: 60 ± 10% R.H.

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

corn oil

Doses:

500, 650, 845, 1000, 1300, 1700, 2200, 2500, 3850 and 5000 mg/kg bw

No. of animals per sex per dose:

10 males and 10 females per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Statistics:

No data

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

1 960 mg/kg bw

Based on:

test mat.

95% CL:

1 620 - 2 370

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

2 280 mg/kg bw

Based on:

test mat.

95% CL:

1 790 - 2 910

Mortality:

Death was noted 1-7 days after administration of 1000 mg/kg and above.

Clinical signs:

other: other: At 500 mg/kg: No toxic symptoms were seen. At 650 and 845 mg/kg: At 1-2 hours after administration, rapid respiration, decrease of motor ataxia and piloerection were developed. The symptoms disappeared within 2-3 days. At 1000 mg/kg and above: In

Gross pathology:

No remarkable changes were found in any groups of the test animals.