Registration Dossier
Registration Dossier
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EC number: 228-391-5 | CAS number: 6258-06-6
Endpoint summary
Administrative data
Description of key information
- Skin: The test substance did not cause skin irritation in the rabbit skin (ECB-IUCLID, 2000).
- Eye: The test substance did not cause irritation of the eye (ECB-IUCLID, 2000).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Data on the skin and eye irritating potential of the test substance is only available as secondary source (ECB-IUCLID, 2000, Val. 4):
Skin irritation
In one study, 500 mg of test substance was applied on the ear of rabbits under semiocclusive conditions for 24 hours. The animals were observed for 7 days. No irritation was observed and no further details were given (Bayer 1979). The second study revealed no skin irritating properites of the test substance. No more details were given (Marhold 1972). No definite prediction was possible from the BfR rules for skin irritation in the OECD toolbox, since the substance fulfilled each two criteria for inclusion and exclusion in the category of skin irritants.
Eye irritation
In one study, 50 mg of the test substance per animal was applied and the animals were observed for 7 days. This test revealed no irritating properties. No further data was given (Bayer 1979).
A second study revealed slighty irritating properties of the test substance when applied to rabbits (Marhold 1972). No further details were given. This information
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
Based on the available data of the test substance, classification for skin and eye irritation under Directive 67/548/EEC is not warranted.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
Based on the available data of the test substance, classification for skin and eye irritation under Regulation (EC) No. 1272/2008 is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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