Registration Dossier
Registration Dossier
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EC number: 254-100-6 | CAS number: 38720-66-0
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Principles of method if other than guideline:
- Determination of solubility in octanol and calculation of log Pow with water solubility reported in section 4.8
- Type of method:
- other: calculation
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 254-100-6
- EC Name:
- Dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 38720-66-0
- Molecular formula:
- C20H10Cl2N2O2
- IUPAC Name:
- 1,8-dichloro-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione; 1,9-dichloro-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione; 2,9-dichloro-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 36.4
- Temp.:
- 24 °C
- pH:
- ca. 7
- Type:
- log Pow
- Partition coefficient:
- 1.56
- Temp.:
- 24 °C
- pH:
- ca. 7
- Details on results:
- Pow and log Pow were calculated from solubilities in octanol (see below) and in water (see section 4.8)
Any other information on results incl. tables
The solubility in octanol was determined to be 1190 µg/L at ambient temperature (24 -25°C). This figure represents the mean of 4 determinations (range: 1180 -1200 µg/L, sigma = 0.01). The solubility in water was determined to be 32.7 µg/L (section 4.8)
These solubilities (equilibrium concentrations considering the tests performed) are used to calculate Pow with the following equation:
Pow = solubility in octanol / solubility in water
Pow = 1190 µg/L / 32.7 µg/L
Pow = 36.4
log Pow = 1.56
Applicant's summary and conclusion
- Conclusions:
- The test item has a log Pow of 1.56.
- Executive summary:
The log Pow of the test substance Pigment Red 209 was calculated from the solubilities (equilibrium concentrations under the test conditions) in water and in octanol. The log Pow at 24 -25 °C was 1.56.
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