Registration Dossier
Registration Dossier
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EC number: 291-378-8 | CAS number: 90388-00-4
Endpoint summary
Administrative data
Description of key information
LD50(oral) > 2000 mg/kg bw (BASF, 2009)
Key value for chemical safety assessment
Additional information
Acute oral toxicity
Two groups, each of three female HanRcc:WIST (SPF) rats, were treated with HEPTADECANOL N by oral gavage administration at a dosage of 2000 mg/kg body weight. The study (BASF, 2009) was conducted according to OECD 423 guideline and GLP. The test item was formulated in olive oil at a concentration of 0.2 g/mL and administered at a dosing volume of 10 mL/kg. The animals were examined daily during the acclimatization period and mortality, viability and clinical signs were recorded. All animals were examined for clinical signs within the first 30 minutes and approximately 1, 2, 3 and 5 hours after treatment on day 1 and once daily during test days 2-15. Mortality/viability was recorded within the first 30 minutes and approximately 1, 2, 3 and 5 hours after administration on test day 1 (with the clinical signs) and twice daily during days 2-15. Body weights were recorded on day 1 (prior to administration) and on days 8 and 15. All animals were necropsied and examined macroscopically. All animals survived until the end of the study period. No clinical signs were observed during the course of the study. The body weight of the animals was within the range commonly recorded for this strain and age. No macroscopic findings were recorded at necropsy. The results obtained within the determination of the content and stability of application formulations confirmed the correct preparation and storage of application formulations during the conduct of this study. The median lethal dose of HEPTADECANOL N after single oral administration to female rats, observed over a period of 14 days is: LD50 (female rat): greater than 2000 mg/kg body weight
Acute inhalation toxicity:
This information is not available
Acute dermal toxicity:
This information is not available
Justification for classification or non-classification
The oral LD50 is > 2000 mg/kg bw for rats. Therefore, the test substance has not to be classified according to EU (67/548/EEC)- and CLP (1272/2008/EC) requirements for this endpoint.
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